There is no immune system; a correct definition would be a conglomerate of cells, organs, chemical reactions, vessels, nodes, and neuronal signals, working together to re-establish the body’s right functions when imbalances, infections, tumors occurred. However, “Science” did classify the immune system as following:
- Innate immune system (not specific, we are born with); all animals on this planet, including sponges, have this immune system.
- Acquired immune system (which develops during our life); this is specific to vertebrates and humans only.
The Healer Sebastian Kneipp (Germany) developed around 1850 – 1895 a cold-water therapy that helped him heal his own TB and dozens of other health conditions. His cure was simple but very efficient: people were walking for ten minutes in cold water. Today this Kneipp cure was addended by walking some minutes in the cold, respectively in warm water; it is a beloved therapy with extraordinary healing effects.
You often hear that vitamin D boosts your immune system; this is true only if you add that the “vitamin D activated” is an immune system booster. How can you activate vitamin D? For example, with cold showers. If for 70 seconds cold water is applied on the lower legs, upper legs, shoulders, arms, and spine, the results were showing a 17% increase of concentration of the active vitamin D. Activated vitamin D is a result of the conversion of passive vitamin D3 stored under the skin (sun exposure, supplementation). After 150 years, Kneipp’s miraculous healing explains that the parathyroid hormone and Vitamin D are activated by the cold. Below you can see “heatmaps of vitamin D
responsive genes for 3 patients before and after vitamin D activation with cold water. Above 25 ng/ml activated vitamin D changes the heatmap of genes significantly. This means activated vitamin D is the trigger controlling gene regulation in our body. Monocytes are also stimulated by activated vitamin D; this secures deep detoxification and fast lymphatic drainage.
Cold causes a stress reaction and engages the Sympathetic nervous system to release Cortisol, Norepinephrine to prepare the body for survival. The parathyroid hormone control loop is autoregulating the body during the cooling process. This performance is valid for everybody leaving their comfort zone, and it is due to the ancestral stress response triggered and controlled by parathyroid hormone, activated vit D, and adrenaline.
Vitamin D is activated when the sun and cold water come together.
- 1928 the German biochemist Adolf Windaus received a Nobel Prize for the discovery of the sensorics-motoric control loop of Calcium and Phosphate
1971 Prof. Michael Holick discovered 1,25 Dihydroxycholecalciferol (activated vitamin D); Holick published in PubMed over 448 scientific paper regarding activated vitamin D
Prof. Armin Zittermann studied the bioactivity of activated vitamin D on the heart; he found that lack of activated vitamin D induces congestive heart failure; he published in PubMed over 84 scientific papers about the influence of activated vitamin D on the cardiovascular system
Calcium and Phosphate are essential for life; therefore, there is a control loop securing sufficient calcium and phosphate in the blood. This control loop has a sensorics signaling system to evaluate the situation and a motoric system to secure the regulatory reaction.
The parathyroid hormone supervises this control loop.
Activated vit. D concentration increases with reduced meat and cheese consumption; meats, sausages, burgers, and cheese contain many phosphates; high Phosphate decreases the Activated vitamin D concentration.
Sport decreases calcium concentration: without supplementing calcium, the control loop must start its work regulating the calcium concentration and thus increases the parathormone. When supplementing 1350 mg of Calcium during exercising (forex using calcium-containing drinks), the calcium parathormone service is less active; thus, less activated vitamin D is produced. Sport activates vit D; however, calcium supplementation decreases the serum concentration in activated vit D. Therefore, calcium consumption must be kept in moderation.
Activated Vitamin D is made in the kidney; if you have severe or chronic kidney disease, you will be immune deficient, and the process of producing activated vitamin D is impaired. Nephropathy will lead to low activated vitamin D manifested with low blood calcium, hyperparathyroidism, osteoporosis, and familial hypophosphatemia. In these cases, treatment with Calcitriol may be indicated only with a health care provider’s supervision.
Several factors affect the activity of vitamin D hydroxylases resulting in significantly different concentration of circulating metabolites:
- Activated vitamin D has a genetic control function, opens the DNA library.
- Activated vitamin D is a neurotransmitter.
- Activated vitamin D acts as antibacterial and anti-viral
- Activated vitamin D works as an anti-carcinogen
- Activated vitamin D works as an electric battery for the skeleton and muscles system.
In the presence of calcium, the body’s electricity functions properly, neuronal cells fire and wire, brain and heart work are in homeostasis. Life expectancy significantly increases with the concentration of active vitamin D; for example, with 78 ng/l, the life expectancy exceeds 100 years. A recent study (Belgium) shows that activated vitamin D below 35 ng/l is a high-risk factor for your life; activated vitamin D below 25 ng/l leads to high mortality.
Wim Hof (‘The Ice Man’) has been often called the “Superhuman.” He holds 26 official Guinness World Records for feats that were believed to be impossible such as: ran half-marathon above Arctic Circle barefoot, remained completely submerged in ice for nearly two hours, climbed Mount Everest in shorts, swam underneath the ice of frozen ocean for the length of a football field on one breath. What is the Wim Hof Method? Breathing exercises, Cold Exposures, Meditation
Endotoxin Study: Bits of dead bacteria (endotoxins) were injected into the bloodstream. The immune system is expected to flare as if it were under attack. This triggers physiological changes, releases of proteins, etc. As a result, the injected person will feel sick (fever, nausea, headache, shivering). Hof was able to dampen the immune response by flooding the blood with adrenaline and triggering key messaging protein IL-10. Was this because Hof has different genetics?
New test with 30 volunteers (18 trained by W. Hof method for 4 days and 12 control). Many parameters tested including blood composition, cytokines, catecholamines, white blood cell count, physiological changes like heart rate, temperature, etc. Result: control group showed normal response to endotoxemia, while the Wim Hof group was successful in dampening the immune response. Hof group had more adrenaline from the start of the experiment, increased IL-10 (interleukin), cytokine, cell-messaging protein, that inhibits the release of other cytokines, contributing to inflammation. Less acute symptoms, faster recovery. Higher release of Il-6, IL-8, TNF-alpha. Even though the inflammatory response was suppressed, white blood cell count was not. Having adrenaline in the blood stirred leukocytosis (an increase of white blood cells)
The immune system was still working in the background, despite the dampened inflammation response.
Cold causes a stress reaction and engages the Sympathetic nervous system to release Cortisol, Norepinephrine to prepare the body for survival. Hof’s sympathetic nervous system was hardly engaged as his body was physiologically primed through Adrenaline’s release.
The parathyroid hormone control loop is autoregulating Win Hof’s body during the cooling process. This performance is valid for everybody leaving their comfort zone, and it is due to the ancestral stress response triggered and controlled by parathormone/activated vit D and adrenaline.